Our pre mixed peptide pens include a case, needle tips and a cartridge filled with your chosen peptide. The pens are easier to use and more accurate than a vial and syringe, and you can top up the kit with individual cartridges for future use.
PEN is an endogenous neuropeptide that binds to GPR83, a heterotrimeric G protein-coupled receptor (GPCR) involved in feeding regulation. PEN and the closely related neuropeptide bigLEN, generated from the same precursor protein (proSAAS), colocalize in brain regions and in Neuro2A cells and bind to GPR83 with similar affinity. Both peptides are also secreted from the same cell population, suggesting that they may interact directly in some neurons of the PVN. Coexpression of GPR83 and PEN in CHO cells increased their binding to each other and changed the signaling properties of both receptors, consistent with a functional interaction.
In the PVN, bath application of mPEN increased the frequency and amplitude of spontaneous excitatory postsynaptic currents sEPSCs in neurons. It also stimulated MAPK (mitogen-activated protein kinase) phosphorylation, an effect that was desensitized after 30 min. In the hippocampus, mPEN bound to and activated GPR83 coupled to Gaq and to a lesser extent to Gai, whereas in the hypothalamus, mPEN acted exclusively on GPR83.
BPC-157 acts as a peptide reversal agent, protecting against the harmful effects of NSAIDs, which are often prescribed for pain relief. It also has impressive wound healing activities. It can reduce excess potassium levels in the body, which leads to a dangerous condition called hyperkalemia.